Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide, including the vast majority of organic work done in the pharmaceutical and agrochemical industries.
One goal of the work at Tampere University of Technology is to further synthesize different types of heterocycles. Previously also solid phase methods have been utilized for the synthesis of indoles.
Indoles have also been used as motif for several chiral ligands for enantioselective synthesis we have recently reported.
"A novel and efficient synthesis of 3-aminomethyl-N-tosyl-indazoles"
(T. Kylmälä,A. Hämäläinen, N. Kuuloja, J. Tois and R. Franzén)
Tetrahedron 66 : 8854 - 8861 (2010)
"Z-Selective synthesis of o-bromo-acetophenone N-tosylhydrazones
and formation of 3-methylindazoles in aqueous ethanol"
(T. Kylmälä, S. Udd, J. Tois and R. Franzén)
Tetrahedron Lett. 51 : 3613 - 3615 (2010)
The collaborative work with Helsinki University of Technology titled
"Copper-catalyzed cyclization of Z-oximes into 3-methyl-1,2-benzisoxazoles "
(S. Udd, R. Jokela, R. Franzén, and J. Tois)
Tetrahedron Lett. 51 : 1030 - 1033 (2010)
Recently written MSc Thesis in this field of research :
" The seven-membered ring in benzodiazepines " written by Noora Katila (2011)
" Synthetic studies towards 2-substituted indoles " written by Teppo Rajala (2010)
Selected poster & oral presentations :
“ Towards efficient preparation of indazoles"
T. Kylmälä, J. Tois, R. Franzén Poster presentation at
The 16th European Symposium on Organic Chemistry (ESOC 16), Prague,
Czech Republic, July 2009.